ER-alpha and ER-beta genotypes predict tamoxifen effects on serum lipids in breast cancer patients
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چکیده
منابع مشابه
ER beta inhibits proliferation and invasion of breast cancer cells.
Recent studies indicate that the expression of ER beta in breast cancer is lower than in the normal breast, suggesting that ER beta could play an important role in carcinogenesis. To investigate this hypothesis, we engineered ER-negative MDA-MB-231 (human breast cancer cells) to reintroduce either ER alpha or ER beta protein with an adenoviral vector. In these cells, ER beta (as ER alpha) expre...
متن کاملLongitudinal Change in Mammographic Density among ER-Positive Breast Cancer Patients Using Tamoxifen.
Tamoxifen-associated mammographic density (MD) reductions are linked to improved breast cancer survival. We evaluated MD at six time points to determine the timing of greatest reduction following tamoxifen initiation. We sampled 40 Kaiser Permanente Northwest estrogen receptor (ER)-positive breast cancer patients from a prior study of MD change, according to tamoxifen use duration and age at di...
متن کاملER-α36, A Novel Biomarker for ER-Negative Breast Cancer
Copyright: © 2016 Wang Y, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Breast cancer is one of the most common cancers among women in the world. The expression level of estrogen receptor-alpha (ER-α)...
متن کاملCorrelation of ER, PR, HER- 2 and P53 Immunoreactions with Clinico-Pathological Features in Breast Cancer
Background and Objectives: The most prevalent malignancy among women is known to be breast cancer (BC). Several factors contribute to determining tumor prognosis and treatment strategies. In this study, the frequency and relevance of these factors are discussed. Materials and Methods: This cross-sectional study was carried out on 214 patients with BC, who referred to the Cancer Institute of...
متن کاملmRNA expression profiles show differential regulatory effects of microRNAs between ER+ and ER- breast cancer
This peer-reviewed article was published immediately upon acceptance. It can be downloaded, printed and distributed freely for any purposes (see copyright notice below). which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.Abstract Background
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ژورنال
عنوان ژورنال: Clinical Pharmacology & Therapeutics
سال: 2004
ISSN: 0009-9236
DOI: 10.1016/j.clpt.2003.11.005